We demonstrate high SARS-CoV-2 burden in nasal tissues and secretions, which coincided with efficient transmission through direct contact. Here, we explored the efficacy of therapeutically administered MK-4482/EIDD-2801 to mitigate SARS-CoV-2 infection and block transmission in the ferret model, given that ferrets and related members of the weasel genus transmit the virus efficiently with minimal clinical signs 6, 7, 8, 9, which resembles the spread in the human young-adult population. 4, 5), that was repurposed for use against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is currently in phase II/III clinical trials (NCT04405570 and NCT04405739).

We previously reported the development of an orally efficacious ribonucleoside analogue inhibitor of influenza viruses, MK-4482/EIDD-2801 (refs. However, approved antiviral treatments such as remdesivir and reconvalescent serum cannot be delivered orally 2, 3, making them poorly suitable for transmission control. Gaining control of the pandemic will depend on the interruption of transmission chains until vaccine-induced or naturally acquired protective herd immunity arises. Widespread community transmission has triggered stringent distancing measures with severe socio-economic consequences. The coronavirus disease 2019 (COVID-19) pandemic is having a catastrophic impact on human health 1.

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